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Chemical structure of bethanecholBethanechol (be-Than-e-kol [key]) is a parasympathomimetic choline ester that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Its chemical structure is Two-((aminocarbonyl)oxy)-N,N,N-trimethyl-One-propanaminium. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will so have a hanker duration of action.
Bethanechol is another time given orally or subcutaneously to treat urinary retention resulting from general anesthetic, or to deal with gi atonicity (want of muscular tone). A muscarinic receptors in the bladder and gastrointestinal tract stimulate contraction of the bladder and expulsion of urine, and increased gi motility, severally. Bethanechol should exist as utilized to address these disorders just when obstruction is ruled out as a imaginable drive.
Apply of bethanechol, also when altogether more muscarinic receptor agonists, is contraindicated within patients by owning asthma, coronary insufficiency, gastroduodenal ulcers, and incontinence. A parasympathomimetic action of this drug may exacerbate a consequences one disorders.
Bethanechol is sold under a br& Duvoid (Roberts), Myotonachol (Glenwood), and Urecholine (Merck Frosst).
Sources
Katzung, Bertram G. Basic & Clinical Pharmacology, Ninth ed. (2004). ISBN 0-07-141092-9
Brenner, G. M. (2000). Materia medica. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
American Pharmacists Association (2000). Compendium of Pharmaceutic & Specialties (Twenty-fifth ed.). Toronto, In: Webcom. ISBN 0-919115-76-4
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